Secondary alkali salts of orthoöxymercuric salicylic acid.



Y and WALTHER SoHRAUTH', ophy, che ists, citizens of the German Em A CORPORATION OF GERMANY.

UNITED STATES PATENT OFFICE.

. WALTER SOHOELLER AND WALTHEB SCHEAUTH,

vCII'O FABBENFABBIKEN VORIM. IBRIEIDR.

OF BERLIN, GERMANY, ASSIGNOBS BAYER & 00., OF ELBERFELD, GERMANY,

SECONDARY ALKALI SALTS OF ORTHOOXYMERCURIC SALICYLIC ACID.

No Drawing.

Specification of Letters Patent Patented Aug, 16, 1910, Application filed Nay 20, 1909. Serial No. 497,303.

(Specimens) To all whom it may concern:

Be it known that we, WALTER SGHOELLER doctors of philosplre, resi; 1g at Berlin, Germany, have invented new" and useful Improvements in Secondary Alkali Salts of Orthooxymercuric Salicylic Acid, of which the followis a specification.

Our present invention relates to the preparation of the hitherto unknown secondary alkaline salts of the ortho-oxymercuric salicylic acidof the formula:

Hon .c,H.. oM .oooM,

M standing for an alkali metal.) These products can be obtained by dissolving the ortho-oxymercuric salicylic anhydrid (hydrargyrum salicylicum) in two molecular proportions of caustic alkali lye, concentratmg the solution, treating it with alcohol and precipitating the new compounds from the alcoholic solution either by the addition of ether, or any other similarmethod. The new compounds thus obtained are slightly colored odorless compounds which are very easily soluble in water, soluble in methyl alcohol and insoluble in ether. dium salt is easily soluble in methylic alcohol and the corresponding calcium salt is easily soluble in a large quantity of water. They have proved to be valuable antisyphilitics characterized by a mild action and the fact that they are non-irritant and not corrosive renders them highly valuable for internal application especially for subcutaneous in ection. They can be used for preparing tablets by means of which aqueous solutions of a distinct amount of mercury can be prepared ith the greatest ease.

e new compounds have proved to be valuable disinfecting agents possessin great disinfecting power. The possess -t e advantage over mercuric Chibl'ld that they do not precipitate albumen that is to say that they are not irritant and that the mercury contained therein does not blackensurgical instruments.

In order to illustrate ournew process the following example i's'fgiven, the arts being by weight :-20 parts of the ort o-oxymercuric compound of salicylic acid anhydrid (hydrargyrum salicylicum) are dissolved in I an aqueous solution of 4.76 parts of NaOH The diso- On analysis the new compound is found to have the formula containing 50.22 per cent. of mercury.

e claim: 1. The herein described new secondary alkaline salts of ortho-oxymercuric salicylic acid of the above given formula obtainable from the ortho-oxymrcuric compound of salicylic acid anhydrid, which are slightly colored compounds easily soluble in water, soluble in methyl alcohol and insoluble in ether; which do not precipitate albumen; and are valuable the-ra eutic compounds, substantially as described.

2. The herein described new secondary sodium salt of ortho-oxymercuric salicylic acid of the above given formula obtainable from the ortho-oxymercuric compound of salicylic acid anhy'drid, which is a whitish product easily soluble in water, soluble in methyl alcohol and insoluble in ether, which does not precipitate albumen; and is a valuable therapeutic compound, substantially as described. g

In testimony whereof we have hereunto set our hands in the presence of two subscribing witnesses.

- 4 WALTER SOHOELLER.

WALTHER SCHRAUTH.

Witnesses HENRY HASPER, WOLDEMAR Ham. 

